Dr. Usha Rajagopal: Nowadays we have some excellent choices for treating the vertical lines around the lip area, both upper and lower lip. I usually recommend a combination of neurotransmitter. I generally like Botox. Most patients need anywhere between 2 and 6 units for the upper lip and, along with that you can do a thin filler like a Volbella or a Belotero. I personally feel like both give excellent results but Volbella tends to last a little bit longer, so my favorite duo combination for vertical lines is Botox with Volbella.